{"created":"2024-04-10T03:19:44.348813+00:00","id":2000151,"links":{},"metadata":{"_buckets":{"deposit":"10af62fd-b8aa-40d8-bcef-5539d64c5427"},"_deposit":{"created_by":18,"id":"2000151","owner":"18","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2000151"},"status":"published"},"_oai":{"id":"oai:matsumoto-u.repo.nii.ac.jp:02000151","sets":["1:1712131276796"]},"author_link":[],"control_number":"2000151","item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicPageEnd":"251","bibliographicPageStart":"249","bibliographic_titles":[{"bibliographic_title":"松本大学研究紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Journal of Matsumoto University","bibliographic_titleLang":"en"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SHARP familyは転写抑制因子であり、SHARP-1およびSHARP-2の2種類のアイソフォームが存在する。Zhx2は、Zhx1、Zhx2、Zhx3の3つのアイソフォームからなるZhx転写抑制因子familyの一員である。これらの転写因子は、マウス3T3-L1脂肪細胞において、セカンドメッセンジャーであるcAMPを産生するアデニル酸シクラーゼの活性化剤であるForskolinにより発現が変動する。本研究では、3T3-L1脂肪細胞での、それぞれの転写因子の標的遺伝子の検索を行うために、ドキシサイクリン存在下でSHARP familyやZhx2を発現できる細胞システムの構築を試みた。現在までに、ドキシサイクリンでmRNAの発現が上昇するクローンは得られたものの、転写因子たんぱく質を発現する細胞株を得るには至れていない。","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"学校法人松商学園松本大学・松本大学松商短期大学部"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11824385","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-0618","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 一哉"}]},{"creatorNames":[{"creatorName":"三崎, 紀展"}]},{"creatorNames":[{"creatorName":"塩谷, 一紗"}]},{"creatorNames":[{"creatorName":"吉田, 瀬七"}]},{"creatorNames":[{"creatorName":"田中, 高志"}]},{"creatorNames":[{"creatorName":"冨田, 晃司"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-12"}],"filename":"matsu_kiyo_22-17.pdf","filesize":[{"value":"247 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://matsumoto-u.repo.nii.ac.jp/record/2000151/files/matsu_kiyo_22-17.pdf"},"version_id":"ceefc216-1d49-4502-97c7-4f7f814ede2e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SHARP family","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Zhx family","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"cAMPシグナル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"標的遺伝子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"3T3-L1 脂肪細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マウス3T3-L1脂肪細胞における各種転写因子遺伝子の発現調節と標的遺伝子の検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス3T3-L1脂肪細胞における各種転写因子遺伝子の発現調節と標的遺伝子の検索","subitem_title_language":"ja"},{"subitem_title":"The Regulation of the Expression of Various Transcription Factor Genes and the Identification of Target Genes in Mouse 3T3-L1 Adipocytes","subitem_title_language":"en"}]},"item_type_id":"2","owner":"18","path":["1712131276796"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-12"},"publish_date":"2024-04-12","publish_status":"0","recid":"2000151","relation_version_is_last":true,"title":["マウス3T3-L1脂肪細胞における各種転写因子遺伝子の発現調節と標的遺伝子の検索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-04-12T08:10:13.238202+00:00"}