{"created":"2023-06-20T15:14:35.620130+00:00","id":1446,"links":{},"metadata":{"_buckets":{"deposit":"f66130ea-1467-494d-a093-a067f1f4a5fb"},"_deposit":{"created_by":7,"id":"1446","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"1446"},"status":"published"},"_oai":{"id":"oai:matsumoto-u.repo.nii.ac.jp:00001446","sets":["1:143"]},"author_link":["1140","1138","1139","1141","1136","1137"],"item_2_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"An Analysis of the Inductive Mechanisms of the ZHX2 Gene Expression in 3T3-L1 Adipocytes and Exploration of the Target Genes"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"176","bibliographicPageStart":"173","bibliographicVolumeNumber":"20","bibliographic_titles":[{},{"bibliographic_title":"The Journal of Matsumoto University","bibliographic_titleLang":"en"}]}]},"item_2_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Zinc-fingers and homeoboxes（ZHX）ファミリータンパク質は、N-末端から2つのzinc-fingerモチーフと5つのhomeodomainを有する転写抑制因子であり、ZHX1、ZHX2、ZHX3の3種のアイソフォームが存在する。これらのうちZHX2は細胞増殖関連遺伝子の転写を促進する転写因子nuclear factor-Y（NF-Y）のAサブユニットと相互作用して転写を抑制する。また、多くのがん細胞で悪性度が高くなるにつれてZHX2遺伝子の発現が低下していることが報告されているが、正常細胞での発現や標的遺伝子に関する研究はなされていない。本研究では、正常細胞のマウス3T3-L1脂肪細胞でcAMP系シグナルによりZHX2遺伝子の発現が上昇することを見いだした。","subitem_description_type":"Abstract"}]},"item_2_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"学校法人松商学園松本大学"}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11824385","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-0618","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 一哉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三崎, 紀展"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 瀬七"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小野, 萌"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 高志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"冨田, 晃司"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-22"}],"displaytype":"detail","filename":"matsu_kiyo_21-16.pdf","filesize":[{"value":"323.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"matsu_kiyo_21-16.pdf","url":"https://matsumoto-u.repo.nii.ac.jp/record/1446/files/matsu_kiyo_21-16.pdf"},"version_id":"6c6e1862-3b5e-4520-8fa4-bc24d13bed06"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nuclear factor-Y","subitem_subject_scheme":"Other"},{"subitem_subject":"ZHXファミリー","subitem_subject_scheme":"Other"},{"subitem_subject":"cAMPシグナル","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"3T3-L1脂肪細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"3T3-L1脂肪細胞におけるcAMP系によるZHX2遺伝子の 発現誘導機構の解析と標的遺伝子の検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"3T3-L1脂肪細胞におけるcAMP系によるZHX2遺伝子の 発現誘導機構の解析と標的遺伝子の検索"}]},"item_type_id":"2","owner":"7","path":["143"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-04-22"},"publish_date":"2023-04-22","publish_status":"0","recid":"1446","relation_version_is_last":true,"title":["3T3-L1脂肪細胞におけるcAMP系によるZHX2遺伝子の 発現誘導機構の解析と標的遺伝子の検索"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2023-06-20T15:21:51.246098+00:00"}